Causes of liver failure are numerous. The liver’s failure to perform its normal role can have devastating or fatal consequences.
Acute-on-Chronic Liver Failure
Acute on chronic liver failure (ACLF) is a syndrome in patients with chronic liver disease with or without previously diagnosed cirrhosis characterized by acute hepatic decompensation resulting in liver failure.
Severe Alcoholic Hepatitis (sAH)
Severe alcoholic hepatitis, or sAH, is defined as progressive inflammatory liver disease, leading to an acute form of alcohol-induced liver injury.
Fulminant Hepatic Failure (FHF)
A relatively rare condition characterized by a rapid deterioration of liver function with altered mental state and coagulopathy. It occurs in individuals without known pre-existing liver disease.
Post-Surgical Liver Failure
Another form of acute liver failure can arise following surgical procedures.
Chronic Liver Failure
Chronic liver failure refers to a gradual loss of liver function and is usually characterized by the presence of widespread cirrhosis.
Limitations of Currently Available Treatment Options for Acute Forms of Liver Failure
Given the liver’s complexity, there are no simple or widely effective medical solutions to acute forms of liver failure. The only long-term cure for acute forms of liver failure is surgical transplantation.